美国科罗拉多一个名叫里德维尔的小镇，一种神秘病毒蔓延其中
为防止病毒蔓延，政府派出部队严防当地居民离开小镇，镇上的医院则人满为患
下士莎拉?伯曼（Mena Suvari 饰）和大兵巴德（Stark Sands 饰）带着她生病的母亲去医院，谁知医院内的患者突然转化成凶残无比、嗜血如命的恐怖僵尸 它们四处攻击为感染者，所有被咬过的人很快也变成僵尸的同类 莎拉和同伴迅速跳上吉普逃亡，却偶然从无线电台中得知她的弟弟特瑞沃（Michael Welch 饰）被困在某栋建筑里的消息 为了救唯一的弟弟，莎拉和同伴再次杀入血肉横飞的僵尸群中……
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